The salary figures on this page are computed estimates, not observed wages. Each one is a national role baseline scaled by a Bureau of Economic Analysis Regional Price Parity cost-of-living multiplier (2025 index) and rounded to the nearest $1,000. No published wage percentile is consulted and no wage survey response enters the calculation, so an Orbyt estimate must not be cited as a Bureau of Labor Statistics figure or as measured pay. The published wage data Orbyt holds is Bureau of Labor Statistics Occupational Employment and Wage Statistics, and Department of Labor H-1B Labor Condition Application filings, which record a filed minimum visa base wage rather than market pay. Where BLS publishes a wage for the occupation a role maps to, it is shown on that role's page as a separate benchmark, labelled with its occupation code, metro area and the number of employed workers it covers. Last updated August 2026.
San Diego, CA has a cost-of-living index of 1.17x the national average. The highest-paying role is Senior VP of Security at $405,000, while the median across all 3,445 roles is $162,000. San Diego's economy thrives on defense, biotech, and a growing tech startup scene.
About the San Diego market
San Diego's economy thrives on defense, biotech, and a growing tech startup scene. The city's proximity to major military installations drives strong aerospace and cybersecurity demand. Biotech companies along the Torrey Pines corridor compete aggressively for scientific and engineering talent, pushing specialized salaries close to Bay Area levels.
Defense & MilitaryBiotech & PharmaTechnologyTourismClean Energy
California's top 13.3% state tax applies here. While San Diego has no city income tax, the state burden means you should negotiate gross pay higher than you might expect for the cost of living.
Negotiating in San Diego
Leverage defense and biotech sector demand. Candidates with security clearances or specialized science backgrounds can command 15 to 20% premiums in San Diego.